Yes, you can experience severe period pain even with low prostaglandin levels. In such cases, the source of the pain is not the prostaglandins themselves. The factors may include a narrow cervical opening (the door between the uterus and vagina), the anatomical positioning of the uterus (if it is tilted or pressing against the bladder or bowel), or gynaecological conditions such as endometriosis, adenomyosis, or uterine fibroids.

Narrow Cervical Opening

If your cervical opening is narrow, your uterus has to exert more physical force to push the lining out, which results in more intense period pain. Conversely, girls who do not experience period cramps typically have an efficient cervical opening that is just wide enough to allow the lining to pass effortlessly.

Infavourable Uterine Position

If your uterus is tilted (retroverted) or pressing against your bladder or bowels, it creates a constant, dull, dragging sensation during your period. This type of pain is not caused by prostaglandins, but rather by the uterus pressing on nearby organs or nerves as it contracts and becomes inflamed during your periods. For girls with no period cramps, the uterus is positioned perfectly straight and doesn’t press against nearby nerves or organ

Gynaecological Conditions & Diseases

If you have gynecological conditions such as endometriosis, adenomyosis, or uterine fibroids, the source of your period pain is the abnormal growth of the uterine lining, which presents differently in each case.

Did you know? If your period pain is caused by excess levels of prostaglandins, it is called primary dysmenorrhea. If it is caused by an underlying gynecological condition—such as endometriosis, adenomyosis, uterine fibroids, or PCOS—it is known as secondary dysmenorrhea.

An educational infographic titled “Can Low Prostaglandin Levels Still Cause Period Pain?” explains that severe period pain can still occur even when prostaglandin levels are low, with causes including a narrow cervix, a tilted uterus pressing on nearby organs, or gynecological conditions such as endometriosis, adenomyosis, and fibroids. It further distinguishes types of menstrual pain, stating that pain caused by excess prostaglandins is called primary dysmenorrhea, while pain resulting from underlying conditions like endometriosis, adenomyosis, uterine fibroids, or PCOS is referred to as secondary dysmenorrhea.The graphic portraits the campaign message "STOP The Period Pain." Which is a knowledge initiative campaign by Blue Cross Laboratories the makers of meftal spas

Your Journey to #StopThePeriodPain Starts Here

Every month, millions of Indian girls & women suffer in silence, told that their severe period pain (dysmenorrhea) is “normal.” Our mission is to break that silence. #StopThePeriodPain campaign is here to empower you with 3 simple truths:

Period Pain Calculator Section

Hit Up Our Period Pain Calculator

For real, how bad is your pain? Our interactive tool uses a 1-10 pain scale and a few quick questions to help you get the full picture. In just a few clicks, you’ll know if your pain is a chill or a major red flag.

Don’t Take Period Pain Lightly.

Period pain (dysmenorrhea) is a real medical issue.
Visit a gynaecologist and #StopThePeriodPain

Don't take period pain lightly